Affiliation:
1. Biotechnology Pharmacology Laboratory CSRD, Peoples University, Bhanpur Bhopal 462037, India
2. Post Graduate Department of Biotechnology and Zoology, Saifia College of Science Bhopal 462001, India
Abstract
Cutaneous pigmentation plays critical role in determining the color of skin along with photo
protection of skin from dreadful effects of ultraviolet radiations. Conversely, abnormal accumulation
of melanin is responsible for hyper pigmentary disorders such as melasma, senile lentigines and freckles.
Because of the visible nature of dermatologic diseases, they have a considerable psychosomatic effect
on affected patients. Tyrosinase inhibitors are molecules that interrelate in some way with the enzyme
to prevent it from working in the normal manner. Past many decades witnessed the quest for the
development of natural tyrosinase inhibitors due to imperative role played by tyrosinase in the process
of melanogenesis and fungi or fruit enzymatic browning. Mechanism of pigmentation is characterized
by the intact process of the synthesis of specialized black pigment within melanosomes. Melanin is
synthesized by a cascade of enzymatic and chemical reactions. For this reason, melanin production is
mainly controlled by the expression and activation of tyrosinase. In the current article, we discussed
tyrosinase inhibitors from the natural sources, which can be an essential constituent of cosmetics products
and depigmenting agents for the treatment of hyperpigmentory disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Reference89 articles.
1. Gertrude E, Costin M, Vincent J. Hearing human skin pigmentation: melanocytes modulate skin color in response to stress.
2. Ali S, Naaz I. Current challenges in understanding the story ofskin pigmentation: Bridging the morpho-anatomical and functionalaspects of mammalian melanocytes in: Muscle cells and Tissue. Intech publications.
3. Lee J, Jung E, Park J, Jung K, Park E, Kim J. Glycyrrhizin Induces Melanogenesis by Elevating a cAMP Level in B16 Melanoma Cells.
4. Ali S, Naaz I. Comparative light and electron microscopic studies of dorsal skin melanophores of Indian toad, Bufo melanostictus.
5. Kim DS, Park SH, Kwon SB, Park ES, Huh CH, Youn SW, Park KC. Sphingosyl phosphoryl choline-induced ERK activation inhibits melanin synthesis in human melanocytes.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献