Affiliation:
1. Department of Chemistry, Laboratory of Analytical Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
Abstract
:
Tricyclic Antidepressants (TCAs) are a group of the main category of antidepressant drugs,
which are commonly prescribed to treat major depressive disorder. Determination of TCA drugs is
very important for clinical and forensic toxicology, especially for therapeutic drug monitoring in various
biofluids. High Performance Liquid Chromatography (HPLC) is a well-established technique for
this purpose. A lot of progress has been made in this field since the past 10 years. Novel extraction
techniques, and novel materials for sample preparation, novel columns and novel applications of analysis
of various biofluids for the determination of TCAs in combination with other drugs are some typical
examples. Moreover, advances have been performed in terms of Green Analytical Chemistry principles.
Herein, we aim to discuss the developed HPLC methods that were reported in the literature for
the time span of 2008-2018.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Reference80 articles.
1. American Psychiatric Association, Depression. psychiatry, ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://psychiatry.org/patients-families/depression/what-is-depression">psychiatry.org/patients-families/depression/what-is-depression (Accessed November 11, 2018).
2. Samanidou V.F.; Nika M.K.; Papadoyannis I.N.; HPLC as a tool in medicinal chemistry for the monitoring of tricyclic antidepressants in biofluids. Mini Rev Med Chem 2008,8(3),256-275
3. Brown W.A.; Rosdolsky M.; The clinical discovery of imipramine. Am J Psychiatry 2015,172(5),426-429
4. Linde K.; Kriston L.; Rücker G.; Jamil S.; Schumann I.; Meissner K.; Sigterman K.; Schneider A.; Efficacy and acceptability of pharmacological treatments for depressive disorders in primary care: Systematic review and network meta-analysis. Ann Fam Med 2015,13(1),69-79
5. Uddin M.N.; Samanidou V.F.; Papadoyannis I.N.; Bio-sample preparation and analytical methods for the determination of tricyclic antidepressants. Bioanalysis 2011,3,97-118
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献