Affiliation:
1. iCBR, Faculty of Medicine, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal
2. CIEPQPF and Faculty of Pharmacy, University of Coimbra, Azinhaga de Sta Comba, Coimbra, Portugal
Abstract
Background:
Cardiovascular diseases are the leading cause of global mortality with a tendency
to increase due to population ageing as well as an increase in associated risk factors. Although
current therapies improve survival rates, they are associated with several side effects, thus justifying
the development of novel preventive and/or therapeutic approaches. In this way, plant metabolites such
as essential oils have emerged as promising agents due to their biological effects.
Objective:
Bearing in mind that several essential oils are characterized by high amounts of phenylpropanoids,
which may play a crucial role in the activity of these volatile extracts, a comprehensive and
systematic review focusing on the cardiovascular effects of phenylpropanoid-rich essential oils is presented.
Methods:
Popular search engines including PubMed, Science Direct, Scopus and Google Scholar were
consulted and papers from 2000 onwards were selected. Non-volatile phenylpropanoids were not considered
in this review.
Results:
A compilation of the current knowledge on this thematic pointed out beneficial effects for
volatile phenylpropanoids namely hypotensive, vasorelaxant, antiplatelet aggregation, antidyslipidaemic
and antidiabetic, as well as protective properties against ischemia/reperfusion injury and heart hypertrophy.
Conclusion:
A better understanding of the protective effects of phenylpropanoids on the cardiovascular
system is presented, thus paving the way towards future research on plant-based therapies for cardiovascular
diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
10 articles.
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