Affiliation:
1. Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal, Karnataka, 576104, India
Abstract
Diphenyl ethers (DPE) and its analogs have exhibited excellent potential for therapeutic and
industrial applications. Since the 19th century, intensive research is perpetuating on the synthetic routes
and biological properties of DPEs. Few well-known DPEs are Nimesulide, Fenclofenac, Triclosan,
Sorafenib, MK-4965, and MK-1439 which have shown the potential of this moiety as a lead scaffold
for different pharmacological properties. In this review, we recapitulate the diverse synthetic route of
DPE moiety inclusive of merits and demerits over the classical synthetic route and how this moiety
sparked an interest in researchers to discern the SAR (Structure Activity Relationship) for the development
of diversified biological properties of DPEs such as antimicrobial, antifungal, antiinflammatory
& antiviral activities.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献