Novel GABAA Agonist Entities: Pharmacological Investigation and Molecular Modeling Study of Thiazolo- and Thiadiazolo-[3,2-a][1,3]diazepine Analogs
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Published:2021-05-19
Issue:9
Volume:21
Page:1048-1057
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ISSN:1389-5575
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Container-title:Mini-Reviews in Medicinal Chemistry
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language:en
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Short-container-title:MRMC
Author:
El-Subbagh Hussein I.1ORCID
Affiliation:
1. Department of Medicinal Chemistry, College of Pharmacy, Mansoura University, Mansoura 35516, Egypt
Abstract
Thiazolo- and thiadiazolo-[3,2-a][1,3]diazepines and their patented derivatives, tested with
diverse CNS pharmacological activities, constitute an important class of compounds for new drug development.
Therefore, research efforts were continued to design, synthesize, and evaluate compounds
for their ultra-short, short-acting hypnotic, anticonvulsant, and neuromuscular blocking activities. The
present review provides a summary of the work accomplished by these heterocycles and their biological
evaluation.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine