Author:
Vijay Srinivasan,Mukkayyan Nagaraja,Ajitkumar Parthasarathi
Abstract
In this study, we show that about 20% of the septatingMycobacterium smegmatisandMycobacterium xenopicells in the exponential phase populationdivideasymmetrically, with an unusually high deviation (17 ± 4%) in the division site from the median, to generate short cells and long cells, thereby generating population heterogeneity. This mode of division is very different from the symmetric division of themajority (about 80%) of the septating cells in theMycobacterium smegmatis,Mycobacterium marinum, andMycobacterium bovisBCG exponential phase population, with 5-10% deviation in the division site from the mid-cell site, as reported by recent studies. The short cells and the long cells further grew and divided to generate a population. We speculate that the generation of the short cells and the long cells through the highly deviated asymmetric divisionin the low proportions of mycobacterial population may have a role in stress tolerance.
Publisher
Bentham Science Publishers Ltd.
Subject
General Immunology and Microbiology
Cited by
20 articles.
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