Affiliation:
1. Department of Medicine, University of California, CA 92653 Irvine, USA
Abstract
Background:
Prostate Cancer (PCa) is a non-cutaneous malignancy in men, and Decipher
being a genomic test, has gained increasing attention in estimating the risk of developing a recurrence
or metastatic PCa disease in patients. Therefore, this study is focused on evaluating the association of
Decipher score risk with recurrence of prostate cancer patients based on their medical, genetic predictors,
and demographics (e.g., races) by conducting a systematic review. Moreover, the study has also
assessed whether Decipher score risk can be a good predictor for prostate patients’ metastasis and
prostate cancer-specific mortality in men and clinical decision-making regarding patient treatment
recommendations.
Methods::
The research study has reviewed 74 research articles, and the systematic review results have
been presented in the form of themes. The studies' review indicated that Decipher acts as a genomic metastasis
signature to predict metastatic disease among patients and make better decisions about treating
the disease. Moreover, this genomic test can also be used in conjunction with Magnetic Resonance Imaging
(MRI) for identifying the lesions that may carry the biological potential for early metastases. Furthermore,
this review also identified that treatment options for PCa might range from Adjuvant Radiation
Treatment (ART) and Salvage Radiation Therapy (SRT) to Radical Prostatectomy (RP); however,
the selection of treatment methodology depends upon the GC score and risk stratification.
Results:
The results further suggested that the occurrence of PCa is two folds greater among African-
Americans (AA) men as compared to non-AA men. Thus, the increasing incidence of PCa among AA
and discrimination within AA's health and socio-economic conditions plays a significant role in treating
AA. In this scenario, the Decipher test score plays an essential role in making treatment decisions.
Conclusion:
To conclude, further trials are still required for validating the Decipher biomarkers, and
scientists should enhance the decipher test ability to be run on a patient's blood samples instead of tumor
tissue, which will help patients use decipher as a screening test at the asymptomatic level.
Publisher
Bentham Science Publishers Ltd.
Subject
Genetics (clinical),Pharmacology,Genetics,Molecular Biology,Molecular Medicine