Mild and Green Protocol for Selective Deuteration of Quercetin-3-ORutinoside (Rutin) Under Aqueous Basic Conditions-Reference-Cited by-同舟云学术

Mild and Green Protocol for Selective Deuteration of Quercetin-3-ORutinoside (Rutin) Under Aqueous Basic Conditions

Published:2019-10-25 Issue:2 Volume:6 Page:147-151
ISSN:2213-3461
Container-title:Current Green Chemistry
language:en
Short-container-title:CGC

Author:

Akolli Anxhela¹,Moretti Silvia²^ORCID,Mangiavacchi Francesca¹,Monti Bonifacio¹^ORCID,Santi Claudio¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, Group of Catalysis and Organic Green Chemistry, University of Perugia, Perugia, Italy

2. Eco Tech, Ponte San Giovanni, Perugia, Italy

Abstract

A convenient and cost-effective method for selective deuteration of rutin using biologically compatible bases and D2O both as a deuterium source and a solvent is herein reported. The protocol is benign and inexpensive affording good results in very mild conditions allowing to reduce the required amount of deuterium oxide. The position of the C-H/C-D exchange and the level of deuteration can be conveniently followed by 1H-NMR.

Publisher

Bentham Science Publishers Ltd.

Subject

General Medicine

Reference14 articles.

1. Banjarnahor S.D.S.; Artanti N.; Antioxidant properties of flavonoids. Med J Indones 2015,23,239-244

2. Procházková D.; Boušová I.; Wilhelmová N.; Antioxidant and prooxidant properties of flavonoids. Fitoterapia 2011,82(4),513-523

3. Hiraoka K.; Miyamoto T.; Baba S.; Furuta T.; Preparation of Deuterium-labeled Rutin by hydrogen exchange reaction. J Labelled Comp Radiopharm 1981,18(5),613-619

4. Faizi S.; Siddiqui H.; Naz A.; Bano S.; Specific deuteration in patuletin and related flavonoids via keto-enol tautomeris: Solvent and temperature dependent 1H-NMR studies. Helv Chim Acta 2010,93,466-480

5. Skaddan M.B.; Yung C.M.; Bergman R.G.; Stoichiometric and catalytic deuterium and tritium labeling of “unactivated” organic substrates with cationic Ir(III) complexes. Org Lett 2004,6(1),11-13

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