Affiliation:
1. Division of Organic Chemistry and Biochemistry, Laboratory for Physical Organic Chemistry, Ruđer Bošković
Institute, Bijenička c. 54, 10000 Zagreb, Croatia
Abstract
Abstract:
The development of more sustainable chemical reactions and processes has been the focus of
recent research activities. Advances in the field of organic synthesis have led to the emergence of new
methodologies and techniques involving non-conventional energy sources. These include the applications
of mechanical energy (mechanochemistry) and microwave radiation (MW) methods. This article reviews
the advances in multistep organic synthesis of biologically relevant organic molecules using
mechanochemistry and microwave techniques. Among them, various heterocyclic molecules (with
nitrogen, oxygen, and sulphur atoms), amides, and peptides have been synthesized by multistep
mechanochemical or MW reactions. Performing multiple synthetic steps using more sustainable methods
shows cumulative advantages over multistep processes under conventional conditions in terms of reduced
solvent use, shorter reaction times, better turnovers, and reaction yields. Simplification of protocols by
carrying out two or more reaction steps in the same reaction vessel is another advantage of multistep
syntheses.
Publisher
Bentham Science Publishers Ltd.
Cited by
2 articles.
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