Affiliation:
1. Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2. Infectious
Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran
3. Department of Infectious Diseases
and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong,
Hong Kong SAR, China
4. Lorestan Provincial Veterinary Service, Khorramabad, Iran
Abstract
Background:
Turmeric (Curcuma longa L.) is a popular spice, containing curcumin that is responsible for its therapeutic effects. Curcumin with anti-inflammatory, antioxidant, anti-cancer, and antimicrobial activities has led to a lot of research focusing on it over the years. This systematic review aimed to evaluate researches on anti-Plasmodium berghei activity of curcumin and its derivatives.
Methods:
Our study was performed according to PRISMA guidelines and was recorded in the database of systematic review and preclinical meta-analysis of CAMARADESNC3Rs (SyRF). The search was performed in five databases, namely Scopus, PubMed, Web of Science, EMBASE, and Google Scholar from 2010 to 2020. The following keywords were searched: “Plasmodium berghei”, “Medicinal Plants”, “Curcumin”, “Concentration”, Animals kind”, “Treatment Durations”, “Routes of Administration” and “in vivo”.
Results:
Of the 3,500 papers initially obtained, 14 articles were reliable and were thus scrutinized. Animal models were included in all studies. The most commonly used animal strain were Albino (43%) followed by C57BL/6 (22%). The other studies used various murine strains, including BALB/c (14%) and ICR (7%). Two (14%) studies did not mention the strain of animal model used. Curcumin alone or in combination with other compounds depending on the dose used, route of administration, and animal model showed a moderate to strong anti-Plasmodium berghei effect.
Conclusion:
According to the studies, curcumin has anti-malarial effects on Plasmodium berghei and, however, its effect on human Plasmodium is unclear. Due to the side effects and drug resistance of current drugs in the treatment of human malaria, the use of new compounds with few or no side effects such as curcumin is recommended as an alternative or complementary treatment
Publisher
Bentham Science Publishers Ltd.
Reference29 articles.
1. Oyelade J.; Isewon I.; Uwoghiren E.; Aromolaran O.; Oladipupo O.; In silico knockout screening of Plasmodium falciparum reactions and prediction of novel essential reactions by analysing the metabolic network. BioMed Res Inter 2018,2018
2. Nateghpour M.; Edrissian G.; Torabi A.; Monitoring of Plasmodium vivax and Plasmodium falciparum response to chloroquine in Bandar-Abbas district, Hormozgan province, Iran. Tehran Univ Med J 2009,67(3),31-38
3. Flegg J.A.; Guérin P.J.; Nosten F.; Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives. Malar J 2013,12(1),411
4. Garedaghi Y.; Khaki A.; Evaluation of the effectiveness of ethanolic extract of solanum surattense against plasmodium berghei in comparison with chloroquine in sourian mice using in vivo tests. Crescent J Med Biol Sci 2014,1(3),76-79
5. Elmi T.; Gholami S.; Azadbakht M.; Ziaei H.; Effect of chloroformic extract of tanacetum parthenium in the treatment of Giardia lamblia infection in Balb/c Mice. J Mazandaran Univ Med Sci 2014,23(1),157-165
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