Rapid Nucleic Acid Reaction Circuits for Point-of-care Diagnosis of Diseases-Reference-Cited by-同舟云学术

Rapid Nucleic Acid Reaction Circuits for Point-of-care Diagnosis of Diseases

Published:2022-03 Issue:8 Volume:22 Page:686-698
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Santiago-McRae Ezry¹^ORCID,Oh Sung Won²,Carlo Anthony Monte³,Bar Omri³,Guan Emily⁴,Zheng Doris³,Grgicak Catherine²,Fu Jinglin²

Affiliation:

1. Center for Computational and Integrative Biology, The State University of New Jersey, Rutgers, USA

2. Center for Computational and Integrative Biology, The State University of New Jersey, Rutgers, USA | Department of Chemistry, Rutgers University-Camden, Camden, NJ 08102, USA

3. Department of Chemistry, Rutgers University-Camden, Camden, NJ 08102, USA

4. High Technology High School, Lincroft, NJ 07738, USA

Abstract

Abstract: An urgent need exists for a rapid, cost-effective, facile, and reliable nucleic acid assay for mass screening to control and prevent the spread of emerging pandemic diseases. This urgent need is not fully met by current diagnostic tools. In this review, we summarize the current state-of-the-art research in novel nucleic acid amplification and detection that could be applied to point-of-care (POC) diagnosis and mass screening of diseases. The critical technological breakthroughs will be discussed for their advantages and disadvantages. Finally, we will discuss the future challenges of developing nucleic acid-based POC diagnosis.

Funder

DoD DURIP

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

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