Affiliation:
1. Laboratorio Nacional de Nanotecnología LANOTEC-CeNAT-CONARE, 1174-1200, San Jose, Costa Rica
2. Independent Researcher, Sao Paulo, Brazil
3. Escuela de Quimica, Universidad de Costa Rica, San Jose 11501-2060, Costa Rica
4. Escuela de Ciencia e Ingenieria de los Materiales, Tecnologico de Costa Rica, Cartago 159-7050, Costa Rica
Abstract
Primarily composed of organic molecules, pharmaceutical materials, including drugs and
excipients, frequently exhibit physicochemical properties that can affect the formulation, manufacturing
and packing processes as well as product performance and safety. In recent years, researchers
have intensively developed Crystal Engineering (CE) in an effort to reinvent bioactive molecules
with well-known, approved pharmacological effects. In general, CE aims to improve the physicochemical
properties without affecting their intrinsic characteristics or compromising their stability.
CE involves the molecular recognition of non-covalent interactions, in which organic materials are
responsible for the regular arrangement of molecules into crystal lattices. Modern CE, encompasses
all manipulations that result in the alteration of crystal packing as well as methods that disrupt crystal
lattices or reduce the size of crystals, or a combination of them. Nowadays, cocrystallisation has been
the most explored strategy to improve solubility, dissolution rate and bioavailability of Active Pharmaceutical
Ingredients (API). However, its combinatorial nature involving two or more small organic
molecules, and the use of diverse crystallisation processes increase the possible outcomes. As a result,
numerous organic materials can be obtained as well as several physicochemical and mechanical
properties can be improved. Therefore, this review will focus on novel organic solids obtained when
CE is applied including crystalline and amorphous, single and multicomponent as well as nanosized
ones, that have contributed to improving not only solubility, dissolution rate, bioavailability permeability
but also, chemical and physical stability and mechanical properties.
Publisher
Bentham Science Publishers Ltd.
Cited by
6 articles.
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