Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its derivatives-Reference-Cited by-同舟云学术

Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its derivatives

Published:2023-05-26 Issue: Volume:20 Page:
ISSN:1570-193X
Container-title:Mini-Reviews in Organic Chemistry
language:en
Short-container-title:MROC

Author:

Mekni Nejib Ben Hussein¹²^ORCID,Medini Faten³,Aroua Lotfi Mohamed⁴⁵

Affiliation:

1. Laboratory of (Bio)Organic Chemistry: Synthesis, Structural and Physico-Chemical Studies (LR99ES14), Department of Chemistry, Faculty of Science of Tunis, El Manar University, 2092, Tunisia

2. Department of Chemistry, College of Science, Qassim University, campus university, King Abdulaziz Road, Al-Malida, 51452-P.O. Box: 6644, Buraydah, Qassim, Kingdom of Saudi Arabia

3. Laboratory of Aromatic and Medicinal Plants, Biotechnology Center of Borj-Cedria, 2050, Carthage University, Tunisia.

4. Laboratory of (Bio)Organic Chemistry: Synthesis, Structural and Physico-Chemical Studies (LR99ES14), Department of Chemistry, Faculty of Science of Tunis, El Manar University, 2092, Tunisia.

5. Department of Chemistry, College of Science, Qassim University, campus university, King Abdulaziz Road, Al-Malida, 51452-P.O. Box: 6644, Buraydah, Qassim, Kingdom of Saudi Arabia.

Abstract

Abstract: Dichlorophosphoryl isocyanate (DCPI) is the most basic and easy phosphoric isocyanate substrate that introduces organic moieties. Synthesized since 1954, the DCPI has a high reactivity toward primary and secondary alkyl, alcohols, phenols, thiols, and amines via the nucleophilic addition reaction on the carbon atom of the isocyanate group. In addition to their synthesis, the resulting products undergo nucleophilic substitutions of the chlorine atoms. Their reactions with nucleophilic and bi-nucleophile reagents yield acyclic and P-heterocyclic compounds, respectively. The resulting compounds have different potential antibacterial, antifungal, and antitumor activities.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry