Pyrazole as an Anti-Microbial Scaffold: A Comprehensive Review

Abstract

Abstract: Pathogenic microorganisms cause serious and lethal infectious diseases. Numerous antimicrobial agents have been developed during the last few decades to treat these infectious diseases, but these are still expanding worldwide. Moreover, microorganisms are developing resistance against commercially available medicines. So, antimicrobial resistance is expanding as the most serious health threat particularly in developing countries, due to the easier availability of anti-microbial drugs. Therefore, the scarcity of effective antibiotics suggests the pressing demand for new anti-microbial agents. Modern drug discovery regarded heterocyclic compounds as its core due to their striking structural characteristics. Pyrazole is considered as a significant heterocyclic nucleus in modern drug development. This review brings a considerable summary regarding derivatives of pyrazole developed over the last decade for their anti-microbial action, along with docking studies carrying an expectation that it will be beneficial for medicinal chemists working in anti-microbial drug development.