Novel Ketosynthases Catalyzing the Non-Decarboxylative Claisen Condensation-Reference-Cited by-同舟云学术

Novel Ketosynthases Catalyzing the Non-Decarboxylative Claisen Condensation

Published:2020-02-28 Issue:2 Volume:17 Page:169-175
ISSN:1570-193X
Container-title:Mini-Reviews in Organic Chemistry
language:en
Short-container-title:MROC

Author:

Pan Lixia¹,Yang Dengfeng²

Affiliation:

1. Guangxi Key Laboratory of Biorefinery, Guangxi Biomass Industrialization Engineering Institute, National Engineering Research Center of Non-food Biorefinery, State Key Laboratory of Non-Food Biomass and Enzyme Technology, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China

2. Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, Guangxi, China

Abstract

In this review, we present the recent advances in unusual novel ketosynthases catalyzing the non-decarboxylative Claisen condensations, including CsyB, MxnB/CorB, Ppys and StlD. The differences are summarized between these non-decarboxylative ketosynthases and the typical decarboxylative ketosynthases. Furthermore, the detailed enzymatic characteristics, structural basis, and catalytic mechanismof these novel ketosynthasesare described. Finally, the prospect of these kind of ketosynthases is discussed.

Funder

Guangxi Natural Science Foundation

National Natural Science Foundation of China

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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