Recent Advances in Chemistry and Biological Activity of 2,6-Diphenyl Piperidines

Abstract

: The review discusses different methods for preparation of 2,6-diphenyl-piperidin-4-one derivatives. 2,6-Diphenyl-piperidin-4-one is prepared from aromatic aldehyde and acetone in ammonium acetate. Reaction of 1-phenylsulfinylpropan-2-one or 1-(4-chlorophenylsulfinyl)propan-2-one, aromatic aldehyde and ammonium acetate gives a series of 2,6-diaryl-2,3-dihydro-1H-pyridin-4-one 6a,b. 4-Phenyl-2-amino-1,3-butadienes reacts with N-allyl benzaldimine through Diels-Alder reaction to afford 2,6-diphenyl-4-piperidinone derivative 7. Also, reactions of 2,6-diphenyl-piperdin-4-one are discussed. The reactions of latter compounds can be on nitrogen atom or carbonyl function group or methylene group adjacent to carbonyl group. In addition, different applications of 2,6-diphenyl-piperidin-4-one are summarized.