Seco-Tetracyclic and Seco-Pentacyclic Triterpenoids from Nature: Phytochemistry, Biological Activity: A Review

Author:

Liu Yingkai1,Jian Yuqing1,Cao Mengru1,Wang Bin1,Qiu Yixing1,Yuan Hanwen1,Zhou Xudong1,Li Bin1,Sheng Wenbing1,Peng Caiyun1,Zhang Zaiqi2,Wang Wei1

Affiliation:

1. TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, P.R. China

2. Hunan University of Medicine, Huaihua, Hunan, 410208, P.R. China

Abstract

: Seco-tetracyclic and seco-pentacyclic triterpenoids are a special class of triterpenoids with ring/rings cleaved on the original skeleton structures. A class of important triterpene derivatives, secotetracyclic and seco-pentacyclic triterpenoids, have long stimulated the interest and attention of botanists and natural products chemists. There is no systematic and comprehensive review for them. This review is focused on the phytochemical investigations and biological activities of seco-tetracyclic and seco-pentacyclic triterpenoids from nature, covering the literature from 2000-2019. This review describes 310 seco-tetracyclic and 139 seco-pentacyclic triterpenoids discovered from 154 species belong to 97 genera, which cover the chemical structures, types, sources, and bioactivities of compounds. The literature from 2000-2019 is reviewed and 208 references are cited.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan province, China

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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