2-Quinolone-Based Derivatives as Antibacterial Agents: A Review

Author:

Moussaoui Oussama1ORCID,Chakroune Said1,Rodi Youssef Kandri1,Hadrami El Mestafa El1ORCID

Affiliation:

1. Laboratory of Applied Organic Chemistry, Faculty of Science and Techniques, Sidi Mohamed Ben Abdellah University, B.P. 2202, Route d ‘Imouzzer, Fez, 30050, Morocco

Abstract

Abstract: The chemistry of 2-quinolones derivatives has received more attention in organic chemistry and medicinal chemistry. Moreover, several advancements in the application of this family of compounds are considered to be of great utility. In recent years, a variety of new, effective, and novel synthetic approaches (including green chemistry, catalyzed and microwave-assisted synthesis) have been discovered and developed for the designing of safe and non-toxic 2-quinolone-based scaffolds to investigate their antibacterial activities. This review summarizes the results of the literature on the synthesis strategies of 2-quinolones derivatives and their reactivity, as well as their antibacterial evaluations against different bacteria strains.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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