Molecular Descriptors and QSSR Models in Asymmetric Catalysis-Reference-Cited by-同舟云学术

Molecular Descriptors and QSSR Models in Asymmetric Catalysis

Published:2022-12 Issue:8 Volume:19 Page:933-938
ISSN:1570-193X
Container-title:Mini-Reviews in Organic Chemistry
language:en
Short-container-title:MROC

Author:

Yu Xinliang¹^ORCID

Affiliation:

1. Hunan Provincial Key Laboratory of Environmental Catalysis & Waste Regeneration, College of Materials and Chemical Engineering, Hunan Institute of Engineering, Xiangtan, Hunan 411104, China

Abstract

Abstract: The 2021 Nobel Prize in Chemistry was awarded to small molecule asymmetric organocatalysis. Quantitative structure−selectivity relationships (QSSR) based on linear free energy relationships are crucial to predicting enantioselectivity in asymmetric catalytic reactions and to gaining insight into the catalytic mechanism. Molecular descriptors describing steric effects and/or electronic effects are described in this review. Subsequently, QSSR models in enantioselective catalysis are analyzed and prospected.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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