Biosynthetic Pathways for Rebeccamycin Family of Natural Products

Author:

Varala Ravi1ORCID,Alam M. Mujahid2ORCID,Kurmarayuni Chandra Mohan3,Bollikolla Hari Babu3,Dubasi Narsimhaswamy4

Affiliation:

1. Scrips Pharma, Mallapur, Hyderabad-500 076, Telangana, India

2. Department of Chemistry, College of Science, King Khalid University, PO Box 9004, Abha 61413, Saudi Arabia

3. Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, Andhra Pradesh, India

4. 12001, Belcher Rd S; Apt No: N226, Largo Florida-33773-5039, USA

Abstract

Abstract: The isolation of Rebeccamycin, a family of indolocarbazole alkaloids from natural sources, and the biosynthesis of this class of compounds are briefly reviewed. Rebeccamycin and its analogues have been extensively studied by medicinal chemists, over the last four decades, due to its wide range of biological activities, predominantly with neuroprotective and antitumor properties.

Funder

Deanship of Scientific Research at King Khalid University, Saudi Arabia

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

Reference93 articles.

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2. Prudhomme M.; Rebeccamycin analogues as anti-cancer agents. Eur J Med Chem 2003,38(2),123-140

3. Mucke H.A.M.; CEP-1347 (Cephalon). IDrugs 2003,6(4),377-383

4. Janosik T.; Rannug A.; Rannug U.; Wahlström N.; Slätt J.; Bergman J.; Chemistry and properties of indolocarbazoles. Chem Rev 2018,118(18),9058-9128

5. Knölker H-J.; Reddy K.R.; Isolation and synthesis of biologically active carbazole alkaloids. Chem Rev 2002,102(11),4303-4427

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