A Comprehensive Review on Synthetic Approaches and Biological Activities
of 1,3,4-oxadiazole
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Published:2022-12
Issue:8
Volume:19
Page:906-919
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ISSN:1570-193X
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Container-title:Mini-Reviews in Organic Chemistry
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language:en
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Short-container-title:MROC
Author:
Kumar Rajnish1ORCID, Kumari Sunita1ORCID, Mazumder Avijit1, Salahuddin 1, Saxena Shivani1ORCID, Sharma Divya1ORCID, Joshi Sagar1ORCID
Affiliation:
1. Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology, (Pharmacy Institute), Plot
No. 19, Knowledge Park-2, Greater Noida, Uttar Pradesh-201306, India
Abstract
Abstract:
Among the large variety of nitrogen and oxygen heterocycles, 1,3,4-oxadiazole scaffold
has attracted considerable attention owing to its ability to perform an extensive range of pharmacological
actions. Therefore, significant efforts of organic chemists have been directed towards the
construction of new drug candidates containing 1,3,4-oxadiazole subunits connected to a known
pharmaceutical or a potential pharmacophore. This paper highlights recent publications on the various
synthesis techniques of 1,3,4-oxadiazole and related compounds over the previous ten years
(2011–2021). The purpose of this review is to present several ways for synthesizing oxadiazole. These
heterocyclics are formed mainly by the cyclization reactions of various reactants under diverse
conditions. A high priority is given to these heterocyclics in literature investigations due to their
pharmacological significance, such as their anticonvulsant, anticancer, antioxidant, antiinflammatory,
antibacterial, antidiabetic activities, etc.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry
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