A Review on Synthetic Strategies for Useful Oxadiazole Derivatives in Psychological Disorders

Abstract

Abstract: Oxadiazole is a five-membered aromatic heterocyclic ring having two nitrogen and one oxygen atom. Various isomeric forms have been reported for oxadiazole, such as 1,3,4-oxadiazole, 1,2,4-oxadiazole, 1,2,5-oxadiazole, etc. Currently, a considerable population worldwide is facing several mental problems due to a competitive lifestyle. The present status of available medicines do not promise complete cure without any adverse effects. Therefore, these disorders are continuously challenging the researchers to come up with new molecules with superior efficacy and minimum side effects. All the isomeric forms of oxadiazole have numerous potential in treating various mental problems such as Parkinsonism, Alzheimer’s, schizophrenia, and epileptic disorders. In this review article, we summarize several recently reported synthetic strategies for preparing different oxadiazole and its derivatives which were found effective in psychological disorders. The researchers will be able to obtain the necessary information (synthesis strategies) through this article for their future research on new molecules containing the oxadiazole moiety. Furthermore, this review article will help the researchers in the fight against mental disorders and highlights possible molecules for the treatment of mentally challenged people.