Synthetic Strategies of Pyrazoline Derivatives for the Development of New Anticancer Agents: Recent Updates.

Abstract

Background: Pyrazoline is a heterocyclic compound of five rings, three carbon atoms, and two nitrogen atoms in a circle with just one endocyclic bond. Pyrazoline is one form of electron-rich nitrogen carrier, gaining popularity because it combines exciting electronic properties with the potential for dynamic applications. Many methods have been used in this research to synthesize pyrazoline derivatives to show a highly biological effect. Objective: The research of pyrazoline derivatives' biological activity has been a fascinating area of pharmaceutical chemistry. Pyrazolines are used in multifunctional applications. The current review of pyrazoline derivatives patent literature (2000-2021) describing the introduction, general method, and synthetic scheme on Anticancer activity has been discussed. Conclusion: Pyrazolines is a known heterocyclic compound. Pyrazoline is a five-membered ring containing three carbon and two nitrogen atoms nearby. Many approaches can be used to figure out their Synthesis. Numerous pyrazoline derivatives have been discovered to have an essential biological effect on anticancer activity, which has encouraged research in this area. The use of pyrazoline against cancer is a brilliant moiety and has an enormous scope of interest for the researchers to search more about this moiety.