Affiliation:
1. Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia
Abstract
Pyrazole is an imperative heterocyclic molecule in the synthetic and medicinal
fields. Pyrazole is stable compound that is particularly used in pharmaceutical applications
(i.e., anticancer, antifungal, antiviral, antimicrobial and antioxidant) and electronic industries.
This review depicted the synthesis of pyrazoles derivatives by employing chalcone
derivatives as a starting material via one and two-pot strategies. The one-pot strategy is an
exclusive method for chalcone cyclization and oxidation, while two-pot strategy is reported
through the preparation of chalcone derivatives, i.e., pyrazoline, hydrazone and bromochalcone
prior to the synthesis of pyrazole. One-pot strategy is frequently reported for pyrazole
synthesis purposes due to unique, stable, reactive and well-known chalcone reactants
having easy handing then two-pot strategy. This review is momentous in organic chemistry,
especially synthesis related to pyrazole and drug industry.
Funder
Universiti Malaysia Sarawak
Ministry of Higher Education
Publisher
Bentham Science Publishers Ltd.
Cited by
11 articles.
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