Microwave-assisted Amination Reactions: An Overview

Author:

Radhika Sankaran1ORCID,Neetha Mohan1ORCID,Aneeja Thaipparambil1ORCID,Anilkumar Gopinathan1ORCID

Affiliation:

1. School of Chemical Sciences, Mahatma Gandhi University, Priyadarsini Hills P.O., Kottayam, Kerala, 686560, India

Abstract

C-N coupling reactions were found to be attractive among researchers owing to the importance of C-N bond formation in heterocyclic synthesis. Hence C-N bond formation via amination reaction with the assistance of microwave radiations gained significant attraction recently. Microwave-assisted reactions are greener, faster and generally efficient compared to the conventional thermal reactions offering better purity of the product with enhancement in the yield. It was surprisingly revealed that several new advancements in amination reactions were highly influenced by this greener technology. This first review on microwave-assisted amination reaction focuses on the novel amination strategies that emerged with the help of microwave methodology, and covers literature up to 2019.

Funder

Kerala State Council for Science Technology and Environment

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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