Affiliation:
1. Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad – 500037,
India
Abstract
Abstract:
Organic azides are in the interphase between chemistry, biology, medicine, and materials science. Their uses in peptide chemistry, combinatorial chemistry, and the synthesis of heterocycles are extensively explored. In this review, the focus is placed on the azido-reductive cyclization of azides and detailed its significant insights. The wide-ranging literature for synthesizing various heterocycles, employing chemoselective and straightforward protocols for azido-reduction with concomitant intramolecular cyclization, has been elaborated. In due course, the azido-reductive cyclization strategy witnessed the synthesis of essential heterocycles such as benzodiazepines, quinazolinones, piperidine, pyrrole and their derivatives. In addition, the review includes applications of azido-reductive cyclization strategies towards the synthesis of various iminosugars, drugs/APIs, and natural products embedding such heterocycles.
Publisher
Bentham Science Publishers Ltd.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献