Affiliation:
1. Department of Chemistry, University of Iowa, Iowa City, IA 52245, USA
Abstract
Abstract:
Asymmetric catalysis with chiral phosphoric acids (CPAs) has impacted a wide
range of organic reactions, including those that generate chiral amines of interest in medicinal
and natural products chemistry. Phosphodiester derivatives (RO)2PO2H offer linkages to various
chiral alcohols and diols, permitting the CPA to transmit stereochemical information to
reactants via ion-pairing and/or H-bonding interactions of the P=O and O–H bonds. This minireview
presents selected recent developments in CPA-catalyzed asymmetric synthesis of
amines, emphasizing innovations from the literature of 2017–2021, with a few earlier examples
to provide additional context. The coverage includes additions to imines, asymmetric
protonation, induction of axial asymmetry, asymmetric Ugi and Passerini multicomponent
coupling reactions, hydroaminations, and Minisci-type additions to heteroaromatic systems.
Publisher
Bentham Science Publishers Ltd.
Cited by
3 articles.
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