Synthesis and In Vitro Antitumor Effect of New Vindoline-steroid Hybrids-Reference-Cited by-同舟云学术

Synthesis and In Vitro Antitumor Effect of New Vindoline-steroid Hybrids

Published:2019-07-31 Issue:8 Volume:23 Page:959-967
ISSN:1385-2728
Container-title:Current Organic Chemistry
language:en
Short-container-title:COC

Author:

Keglevich András¹,Zsiros Vivian²,Keglevich Péter¹,Szigetvári Áron³,Dékány Miklós³,Szántay Csaba³,Mernyák Erzsébet⁴,Wölfling János⁴,Hazai László¹

Affiliation:

1. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Hungary

2. Quality Process Development Department, Egis Pharmaceuticals Plc., H-1106 Budapest, Kereszturi ut 30-38, Hungary

3. Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Hungary

4. Department of Organic Chemistry, University of Szeged, H-6720 Szeged, Dom ter 8, Hungary

Abstract

10-Aminovindoline and 17-desacetylvindoline were coupled with 5α- dihydrotestosterone hemisuccinate and 19-nortestosterone hemisuccinate. As a result, four vindoline-steroid hybrids were synthesized via a succinate linker. One of the new hybrid compounds showed significant anticancer effect in vitro in the case of colon cancer and melanoma cell lines.

Funder

Hungarian Scientific Research Fund

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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