Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine-Reference-Cited by-同舟云学术

Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine

Published:2019-07-16 Issue:7 Volume:23 Page:852-858
ISSN:1385-2728
Container-title:Current Organic Chemistry
language:en
Short-container-title:COC

Author:

Keglevich András¹,Szigetvári Áron²,Dékány Miklós²,Szántay Csaba²,Keglevich Péter¹,Hazai László¹

Affiliation:

1. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Hungary

2. Spectroscopic Research Department, Gedeon Richter Plc., H-1475 Budapest, 10, P. O. Box 27, Hungary

Abstract

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.

Funder

Hungarian Scientific Research Fund

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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