A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer-Reference-Cited by-同舟云学术

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

Published:2020-05-17 Issue:5 Volume:24 Page:473-486
ISSN:1385-2728
Container-title:Current Organic Chemistry
language:en
Short-container-title:COC

Author:

da Silveira Pinto Ligia S.¹,Vasconcelos Thatyana R. Alves¹,Gomes Claudia Regina B.²,de Souza Marcus Vinícius N.²

Affiliation:

1. Universidade Federal Fluminense, Instituto de Quimica, Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica. Outeiro de Sao Joao Batista, s/no, Centro, Niteroi, 24020-141, Rio de Janeiro, Brazil

2. Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos-Farmanguinhos. Rua Sizenando Nabuco 100, Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil

Abstract

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry

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