Affiliation:
1. Department of Chemistry, School of Science, Alzahra University, Tehran, Iran
2. Department of Chemistry, Shahid Beheshti University, Tehran, Iran
Abstract
Bicyclic compounds derived from pyrazine and aromatic five-membered heterocycles including thiophene, furan and pyrrole show various biological and pharmacological proBicyclic compounds derived from pyrazine and aromatic five-membered heterocycles including thiophene, furan and pyrrole show various biological and pharmacological properties, such as anti-inflammatory, antiviral, antitumor, antioxidant, antimycobacterial, and cytostatic activities. In many cases, it has been demonstrated that there are more potent cytostatic and cytotoxic agents against human tumor cell lines, leukemia, colon cancer, central nervous system cancer, melanoma, ovarian cancer, prostate cancer and breast cancer. They are also useful precursors for the large scale preparation of inorganicorganic hybrid solar cells, suitable acceptors for the synthesis of low-band gap polymers. They use ligands for serotoninergic 5-HT7 receptor and are effective in neurogical and psychiatric diseases, antimalarial, neuroleptic and cardiovascular. The absence of any useful review concerning the chemistry and synthesis of the above-mentioned heterocyles encouraged us to underscore the recent advances in chemistry and synthetic approaches leading to the preparation of thienopyrazines, pyrrolopyrazines and furopyrazines since 1990.perties such as anti-inflammatory, antiviral, antitumor, antioxidant, antimycobacterial, and cytostatic activities. In many cases, it has been demonstrated that they are much more potent cytostatic and cytotoxic agents against human tumor cell lines, leukemia, colon cancer, central nervous system cancer, melanoma, ovarian cancer, prostate cancer and breast cancer. They also are useful precursors for the large scale preparation of inorganic-organic hybrid solar cells, suitable acceptors for the synthesis of low-band gap polymers. They use as ligands for serotoninergic 5-HT7 receptor and being effective in neurogical and psychiatric diseases, antimalarial, neuroleptic and cardiovascular. Due to the absence of any useful review concerning the chemistry and synthesis of the above-mentioned heterocyles encouraged us to underscore the recent advances in the chemistry and synthetic approaches leading to preparation of thienopyrazines, pyrrolopyrazines and furopyrazines from 1990 up to date.
Publisher
Bentham Science Publishers Ltd.
Reference151 articles.
1. Tišler M.; Stanovnik B.; Pyridazines and their benzo derivatives. Compr Heterocycl Chem 1984,3,1-56
2. Selvam Th.P.; James C.R.; Dniandev Ph.V.; Valzita S.K.; A mini review of pyrimidine and fused pyrimidine marketed drugs. Res Pharm 2012,2,1-9
3. Seitz L.E.; Suling W.J.; Reynolds R.C.; Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives. J Med Chem 2002,45(25),5604-5606
4. Asif M.; The pharmacological importance of some diazine containing drug molecules. SOP Trans Org Chem 2014,1,1-16
5. Somerville R.L.; Encyclopedia of Genetics 2001
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