Nitrogen-containing Fused Heterocycles: Organic Synthesis and Applications as Potential Anticancer Agents

Abstract

Abstract: The fused Nitrogen heterocyclic compounds and their derivatives have grown in prominence over the past several decades as a result of their significant medical value. The adaptable and easily synthesized N-Heterocyclic scaffolds are particularly exciting in both synthetic organic chemistry and the biological sector due to their powerful pharmacological properties, which are taken into consideration while considering their numerous uses. For the synthesis of N-heterocycles and their derivatives, several attempts were undertaken to create a variety of synthetic protocols. The N-Heterocyclic compounds provide a variety of adaptable structures for specific biological applications and represent novel, broad-spectrum antibacterial and anticancer agents. They typically have minimal toxicity profiles. The majority of these N-Heterocycles have demonstrated more cytotoxicity than the effective anticancer medication cisplatin. The design, synthesis, structural characterisation, and biological uses of N-Heterocycles are reviewed in this work. In this article, the developments made in this specific field are comprehensively examined.