Affiliation:
1. Department of Chemistry, Chandigarh University, Gharuan-140413, Mohali, Punjab, India
Abstract
Seven membered heterocyclic Azepine and its derivatives have great pharmacological
and therapeutic implications. In this review, the literature of the last fifty years has
been exploited for the synthesis, reaction, and biological properties of these seven-member
heterocyclic compounds. Most of the mechanisms involved the ring expansion of either five
or six-membered compounds using various methods such as thermally, photo-chemically, and
microwave irradiation. The systematically designed schemes involve the synthesis of different
derivatives of azepine, azepinone, azepane, etc., using similar moieties by various researchers.
However, there is much work yet to be done in the biological section, as it is not
explored and reported in the literature; therefore, N-containing seven-membered heterocycles
still have much scope for the researchers.
Publisher
Bentham Science Publishers Ltd.
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