Affiliation:
1. Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
Abstract
Background:
Hepatocellular carcinoma (HCC) is one of the most common malignant
tumors with a dismal prognosis, according to updated statistics. The solute carrier family 17 member
2 (SLC17A2) has not been studied in liver cancer. Therefore, we evaluated the role of
SLC17A2 in HCC by bioinformatics analysis.
Objective:
The objective of the study was to explore the value of SLC17A2 in the prognosis and
diagnosis of hepatocellular carcinoma.
Method:
The expression level of SLC17A2 in HCC and the clinicopathological data were analyzed
based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and
validated by immunohistochemical staining. In addition, the Kaplan–Meier plotter database and receiver
operating characteristic (ROC) curve analysis were used to explore the prognostic and diagnostic
significance. Some online databases were used to analyze the relationship between immune
cell infiltration and analyze the relationship between immune cell infiltration and SLC17A2 in
HCC.
Results:
Multivariate Cox regression analysis showed that SLC17A2 expression was low in HCC
(P < 0.05) and closely related to the clinical stage of HCC. In addition, SLC17A2 had a certain diagnostic
value in HCC according to ROC curve analysis. Further biological analyses showed that
SLC17A2 can regulate fatty acid metabolism, amino acid metabolism and cytochrome P450-
related metabolism. Notably, we found that SLC17A2 expression was closely correlated with the
infiltration of most immune cells in HCC.
Conclusion:
SLC17A2 expression is low in HCC and correlates with immune infiltration, so it
may serve as an independent prognostic factor for HCC.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Cited by
1 articles.
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