Green Synthesis of Thiazole Derivatives using Multi-component Reaction of Aldehydes, Isothiocyanate and Alkyl Bromides: Investigation of Antioxidant and Antimicrobial Activity

Abstract

Aims & Objective: In this work, the multicomponent reaction of aldehydes, benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide and a catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in the water at 100oC was investigated. Materials and Methods: In these reactions, thiazole derivatives were produced in good to excellent yields and short time. Also, the antioxidant activity was studied for some newly synthesized compounds using the DPPH radical trapping and reducing of ferric ion experiments and comparing results with the synthetic antioxidants (TBHQ and BHT). Results: As a result, the compounds 4b showed excellent DPPH radical trapping and reducing the strength of ferric ion. These compounds have biological potential because of the thiazole core. For this reason, the antimicrobial activity of some synthesized compounds was studied by employing the disk diffusion test on Gram-positive bacteria and Gram-negative bacteria. Conclusion: The results of the disk diffusion test showed that these compounds prevented bacterial growth.