Affiliation:
1. Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran, Iran
Abstract
Aim and Objective:
Nano-2-[N',N'-dimethyl-N'-(silica-n-propyl)ethanaminium chloride]-N,N-dimethylaminium
bisulfate (nano-[DSPECDA][HSO4]) was used as a highly effective and heterogeneous silica-based nanostructured catalyst
for the synthesis of 1-thioamidoalkyl-2-naphthols and substituted tetrahydropyridines.
Material and Methods:
The expected products were prepared in mild conditions. In this work, three novel 1-
thioamidoalkyl-2-naphthols and two new tetrahydropyridine derivatives were synthesized and characterized by IR, 1H and
13C NMR and Mass spectroscopy.
Results:
One-pot multi-component condensation of 2-naphthol with arylaldehydes and thioacetamide catalyzed by nano-
[DSPECDA][HSO4] under green, mild and solvent-free conditions led to 1-thioamidoalkyl-2-naphthols in high yields. The
nanocatalyst was also used for the preparation of functionalized tetrahydropyridines by the one-pot multi-component reaction of anilines, arylaldehydes and ethylacetoacetate under solvent-free and mild conditions.
Conclusion:
The reactions results are better compared to the literature in terms of one or more of these factors: yield, time,
and the reaction media. All the products were purified by recrystallization from EtOH, and without column chromatography,
which is good agreement with the green chemistry protocols.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Cited by
1 articles.
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