Affiliation:
1. Department of Histology and Embryology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang, China
2. Department of Pharmacology, School of Pharmacy College, Xinjiang Medical University, Urumqi, Xinjiang, China
Abstract
Background:
Head and neck squamous cell carcinoma (HNSCC) is a common cancer
that is characterized by a complex pathogenesis. Only limited data are available on the primary
pathogenic genes and pathways in HNSCC.
Objective:
This study aimed to identify potential biomarkers of HNSCC and explore its underlying
mechanisms.
Methods:
We screened differentially expressed genes (DEGs) using the Gene Expression
Omnibus(GEO) database. Gene Ontology (GO) and Reactome pathway enrichment were analyzed
using the STRING database. The protein-protein interaction network of the DEGs was
reconstructed using Cytoscape software in STRING. The ONCOMINE and UNLCAN databases
were used to identify the expression of hub genes. In addition, we employed UNLCAN to correlate
tumor grade with key genes.
Results:
Finally, the effect of hub genes on overall survival (OS) was analyzed using the Kaplan-
Meier method. In total, 22 DEGs were identified. These were related to the mitotic cell cycle,
mitotic G1-G1, and S phases, G2/M transition, NOTCH signaling, and regulation of TP53 activity.
Seven hub genes were screened with Cytoscape. Increased expression of five hub genes (AURKA,
BIRC5, MKI67, UBE2C, and TOP2A) was related to a higher tumor grade and worse OS.
Conclusion:
We have identified five key genes that may help us understand the carcinogenic
mechanisms related to the cell cycle in HNSCC. These genes may be used as biomarkers for
survival and treatment of HNSCC.
Funder
Educational Research and Reform Project of Xinjiang Medical University
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Cited by
2 articles.
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