Dynamic Behavior of Biomaterials Uncovered by Cryo-electron Microscopy
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Published:2021-06-21
Issue:7
Volume:24
Page:1007-1016
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ISSN:1386-2073
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Container-title:Combinatorial Chemistry & High Throughput Screening
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language:en
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Short-container-title:CCHTS
Author:
Zhao Yimin1,
Zhao Yizhen1,
Peng Bingquan1,
Zhang Lei1
Affiliation:
1. MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Science, Xi’an Jiaotong University, Xi’an 710049, China
Abstract
Structural biology develops rapidly with time. The static structure analysis of
biomaterials is not enough to satisfy the studies of their functional mechanisms, with a huge
obstacle for the dynamic process of biological complexes. The rapid development of cryo-electron
microscopy (cryo-EM) technology makes it possible to observe the near-atomic resolution
structures and dynamic nature of biological macromolecules, in the fields of dynamic
characteristics of proteins, protein-protein interactions, molecular recognition, and structure-based
design. In this review, we systematically elaborate the contribution of cryo-EM technology in the
field of biomaterials such as ribosome motion, membrane protein structure and conformational
space, dynamic transmission within the plasma membrane and clinical applications. We also put
forward a new standpoint in the development of cryo-EM technology.
Funder
Natural Science Basic Research Plan in Shaanxi Province of China
Fundamental Research Funds for the Central Universities
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine