A Comprehensive Review of Structures, Structure-activity Relationships,
Extractions, and Bioactivities of Flavonoids from Citrus medica
-
Published:2023-11
Issue:14
Volume:26
Page:2411-2423
-
ISSN:1386-2073
-
Container-title:Combinatorial Chemistry & High Throughput Screening
-
language:en
-
Short-container-title:CCHTS
Author:
Chen Jie1, He Nengxin1, Wang Qinyuan1, Wu Guang1, Wu Wenxia1, Xin Qiang1, Cheng Guangyu1, Sang Zhipei23, Zhu Caiqing4, Wu Yongzhong5, Wei Rongrui1, Ma Qinge1
Affiliation:
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center
of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese
Medicine, Nanchang 330004, China 2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University,
Nanyang 473061, China 3. School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China 4. Laboratory of Natural Pharmaceutical Chemistry, Jiangxi Medical Device Testing Center, Nanchang 330029, China 5. Laboratory of Natural Pharmaceutical Chemistry, Jiangxi Puzheng Pharmaceutical Co., Ltd., Ji’an 331400, China
Abstract
Background::
Citrus medica is a kind of medicinal and edible plant. It not only contains rich nutrients but also has a variety of therapeutic functions, including relieving pain, harmonizing the stomach, removing dampness, reducing phlegm, cleaning the liver, and relieving qi in traditional Chinese diagnosis.
Methods::
The references of C. medica were mainly collected from the online database, such as PubMed, SciFinder, Web of Science, Google Scholar, Elsevier, Willy, SpringLink, and CNKI. The other related references were sorted by consulting books and documents.
Results::
This review summarized and analyzed the different types of flavonoids of C. medica, including flavone-O-glycosides, flavone-C-glycosides, dihydroflavone-O-glycosides, flavonol aglycones, flavonoid aglycones, dihydroflavonoid aglycones, and bioflavonoids. The extraction methods of flavonoids were summarized in this review. Meanwhile, the multiple bioactivities of these flavonoids, including anti-atherosclerotic, hypolipidemic, anti-oxidant, hypoglycemic, and other activities. Their structure-activity relationships were reviewed and discussed in this paper.
Conclusions::
This review summarized the different extraction methods of diverse flavonoids with multiple bioactivities of C. medica, and their structure-activity relationships were discussed in this paper. This review may provide a valuable reference for researching and exploiting C. medica.
Funder
Science and Technology Project of Jiangxi Administration of Traditional Chinese Medicine Science and Technology Project of Jiangxi Provincial Department of Education Jiangxi Provincial Natural Science Foundation Science and Technology Project of Jiangxi Health Commission Doctoral Research Initiation Fund Project of Jiangxi University of Traditional Chinese Medicine
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Computer Science Applications,Drug Discovery,General Medicine
Reference75 articles.
1. Chen Z.Y.; Wang Y.J.; Xu Q.Y.; Han X.X.; Hu Q.M.; Yang L.; Chen E.R.; Liao F.L.; Guo W.D.; CmsCRC is involved in regulated fingers stretch in Citrus medica and activated under lower temperature. Yuan Yi Xue Bao 2019,46,2143-2154 2. Jian S.F.; Gong S.; Ma Y.H.; Liu T.K.; Gong J.Y.; Yi Y.; Liu W.H.; Research progress on chemical structures, extraction methods, and bioactivities of bergamot flavonoids. Food Res Dev 2021,42,198-204 3. Li C.Y.; Yuan Z.; She C.J.; Bi J.Y.; Research progress on chemical constituents and pharmacological actions of Citrus medica. Food Drug 2022,24,187-192 4. Chen J.; Wu G.; Zhu C.Q.; Wu Y.Z.; Wei R.R.; Ma Q.G.; Structurally diverse flavonoids from Citrus medica and their multiple bioactivities: A review. J Food Nutr Res 2022,10,81-87 5. Zhang Y.; Kong L.Y.; Studies on the constituents of Citrus medica. Zhongguo Xiandai Zhongyao 2006,8,16-17
|
|