Alkaloids as Potential Anti-HIV Agents

Author:

Rani Nidhi1,Singh Randhir2,Kumar Praveen3,Sharma Prerna4,Kaur Rajwinder1,Arora Rashmi1,Singh Thakur Gurjeet1

Affiliation:

1. Chitkara College of Pharmacy, Chitkara University, Punjab, India

2. Department of Pharmacology, Central University, Bathinda

3. SunPharma, Hill Top Area, Vill. Bhatolikalan, P.O.Barotiwala, Distt.Solan, Himachal Pardesh, 174103, India

4. Guru Gobind Singh College of Pharmacy, Yamuna Nagar, India

Abstract

Background: Alkaloids are nitrogen-containing compounds that are naturally occurring and have a variety of biological activities, including antimicrobial properties. In this study, the authors used a molecular docking approach to evaluate the anti-HIV potential of 64 alkaloids. Methods: The authors used the Molegro Virtual Docker software to dock the alkaloids into the active sites of three HIV enzymes: protease, integrase, and non-nucleoside reverse transcriptase (NNRT). The docking scores were used to assess the potential of the alkaloids to inhibit the enzymes. Results: The results showed the alkaloids to have good potential to inhibit the enzymes. Tubocurarine and reserpine were found to be the most potent alkaloids, with docking scores of -123.776 and - 114.956, respectively. Conclusion: The authors concluded that tubocurarine and reserpine could be further promoted as potential lead molecules for the development of new anti-HIV drugs.

Publisher

Bentham Science Publishers Ltd.

Subject

Virology,Infectious Diseases

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