Author:
Syed Ehsan Ullah,Wasay Mohammad,Awan Safia
Abstract
Background/Objective:
Recent literature has identified links between vitamin B12 deficiency and depression.We compared the clinical response of SSRI-monotherapy with that of B12-augmentation in a sample of depressed patients with low normal B12 levels who responded inadequately to the first trial with the SSRIs.
Methods:
Patients with depression and low normal B12 levels were randomized to a control arm (antidepressant only) or treatment arm (antidepressants and injectable vitamin B12 supplementation).
Results:
A total of 199 depressed patients were screened. Out of 73 patients with low normal B12 levels 34 (47%) were randomized to the treatment group while 39 (53%) were randomized to the control arm. At three months follow up 100% of the treatment group showed at least a 20% reduction in HAM-D score, while only 69% in the control arm showed at least a 20% reduction in HAM-D score (p<0.001). The findings remained significant after adjusting for baseline HAM-D score (p=0.001).
Conclusion:
Vitamin B12 supplementation with antidepressants significantly improved depressive symptoms in our cohort.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health,Clinical Neurology,Neurology
Reference25 articles.
1. Murray C, Lopez A.
The global burden of diseases a comprehensive assessment of Mortality and disability from diseases injuries and risk factors in 1990 and projected to 2020
Boston Harvard School of Public Health WHO and World Bank
1996.
2. Mirza I, Jenkins R.
Risk factors prevalence and treatment of anxiety and depressive disorders in Pakistan systematic review
BMJ
2004;
328
: 794-8.
3. Sohail Z, Ed.
American Psychiatric Association
Practice Guideline for the Treatment of Patients With Major Depressive Disorder DOI101176/appibooks9780890423387654001. 3rd ed..
4. Thase ME, Entsuah AR, Rudolph RL.
Remission rates during treatment with Venlafaxine or selective serotonin reuptake inhibitors
Br J Psychiatry
2001;
178
: 234 -41.
5. Puech A, Montgomery SA, Prost JF, Solles A, Briley M.
Milnacipran,a new serotonin and Noradrenaline reuptake inhibitor an overview of its antidepressant activity and clinical tolerability
Int Clin Psychopharmacol
1997;
12
(2)
: 99-108.
Cited by
65 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献