Affiliation:
1. Department of Biochemistry and Molecular Biology, Sciences Center, Federal University of Cear, Campus do Pici,
CEP-60440-554, Fortaleza, Ceará - CE, Brazil
2. Department of Physiology and Pharmacology, Drug Research and
Development Center, Federal University of Ceará, Fortaleza, 60430-275, Brazil
Abstract
Abstract:
Due to the excessive and inappropriate use of antibiotics in farming and clinic, pathogens
developed resistance mechanisms to currently used drugs. Thus, because of this resistance,
drugs become ineffective, leading to public health problems worldwide. According to the World
Health Organization (WHO), microbial resistance to drugs is one of the most threats that humanity
must face. Therefore, it is imperative to seek alternative methods to overcome microbial resistance.
Here, the potential of natural or synthetic antimicrobial peptides to overcome microbial resistance
will be discussed, and how peptides could be a source for new therapeutics molecules. In this context,
antimicrobial peptides (natural or synthetic) are considered promising molecules based on
their antifungal, antiviral, and antibacterial properties, making them eligible for developing new
drugs. In addition, they can act synergistically with existing drugs on the market, revealing a broad
spectrum of applications.
Funder
CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológico
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine