Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis-Reference-Cited by-同舟云学术

Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis

Published:2024-01 Issue:1 Volume:25 Page:59-70
ISSN:1389-2037
Container-title:Current Protein & Peptide Science
language:en
Short-container-title:CPPS

Author:

Salimi Zohreh¹,Rostami Mehdi²,Milasi Yaser Eshaghi¹,Mafi Alireza¹³,Raoufinia Ramin⁴⁵,Kiani Amirhossein⁶,Sakhaei Fariba⁷,Ghezelbash Behrooz⁸,Butler Alexandra E.⁹,Mohammad-Sadeghipour Maryam¹⁰,Sahebkar Amirhossein¹¹¹²

Affiliation:

1. Department of Clinical Biochemistry, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3. Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4. Medical Genetics and Molecular Medicine Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5. Neyshabur University of Medical Sciences, Neyshabur, Iran

6. Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

7. Department of Clinical Biochemistry, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

8. Department of Immunology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran

9. Research Department, Royal College of Surgeons in Ireland, Bahrain, PO Box 15503, Adliya, Bahrain

10. Department of Clinical Biochemistry, Afzalipoor Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

12. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Abstract: Frequent exposure to various external and internal adverse forces (stresses) disrupts cell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. This process leads to the unfolded protein response (UPR), which aims to re-establish/maintain optimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, fibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to activating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of the consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and specifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.

Publisher

Bentham Science Publishers Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,General Medicine