Research Progress of Pectin Methylesterase and its Inhibitors

Author:

Guo Xiaoqiang1,Chang Shan2,Hu Jianping3,Wang Yueteng1,Zhang Derong4,Huang Lifen1,Zhang Zelan1,Gao Jiaxing1,Liu Wei1,He Gan4

Affiliation:

1. Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu 610106, China

2. Institute of Bioinformatics and Medical Engineering, School of Electrical and Information Engineering, Jiangsu University of Technology, Changzhou 213001, China

3. Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, School of Pharmacy, Chengdu University, Chengdu 610106, China

4. School of Marxism, Chengdu Vocational & Technical College of Industry, Chengdu 610081, China

Abstract

Abstract: As an important pectin enzyme, pectin methylesterase (PME) can hydrolyze methyl esters, release methanol and reduce esterification. It is essential in regulating pollen tube development, root extension, and fruit ripening. Pectin methylesterase inhibitors (PMEI) can specifically bind PME and inhibit its activity, which jointly determines the esterification degree of pectin. PMEI has important application prospects in plant pest control, fruits and vegetable processing fields. In this paper, the gene families, crystal structures, molecular recognition, and applications in plants and industry are reviewed for the PME and PMEI systems. Finally, the semi-rational design of PMEI is discussed and discussed prospected.

Funder

National Natural Science Foundation of China

Sichuan Science and Technology Program

Project of Key Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department

Publisher

Bentham Science Publishers Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,General Medicine

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