Affiliation:
1. Department of Medical Services and Techniques, Sabuncuoğlu Serefeddin Health Services Vocational School,
Amasya University, 05100, Amasya, Turkey
2. Division of Exercise and Sport Physiology, Faculty of Sport Sciences, Hacettepe University, 06800, Ankara, Turkey
3. Division of Exercise Nutrition and Metabolism, Faculty of Sport Sciences, Hacettepe University, 06800, Ankara, Turkey
Abstract
Abstract:
Physical inactivity is a major cause of chronic diseases. It shortens the health span by lowering
the age of the first chronic disease onset, which leads to decreased quality of life and increased
mortality risk. On the other hand, physical exercise is considered a miracle cure in the primary prevention
of at least 35 chronic diseases, including obesity, insulin resistance, and type 2 diabetes. However,
despite many scientific attempts to unveil the health benefits conferred by regular exercise, the underlying
molecular mechanisms driving such benefits are not fully explored. Recent research shows that
exercise-induced bioactive molecules, named exerkines, might play a critical role in the regulation of
metabolic homeostasis and thus prevent metabolic diseases. Here we summarize the current understanding
of the health-promoting effects of exerkines secreted from skeletal muscle, adipose tissue,
bone, and liver, including MOTS-c, BDNF, miR-1, 12,13-diHOME, irisin, SPX, OC, GDF15, and
FGF21 on obesity, insulin resistance, and type 2 diabetes. Identifying the systemic health benefits of
exerkines may open a new area for the discovery of new pharmacological strategies for the prevention
and management of metabolic diseases.
Funder
Scientific and Technological Research Council of Turkey
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine
Cited by
6 articles.
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