Affiliation:
1. Department of Biotechnology & Bioinformatics, School of Life Sciences, University of Hyderabad, Prof. C.R. Rao
Road, Hyderabad 500046, India
Abstract
Abstract:
Human parasites cause several diseased conditions with high morbidity and mortality in a
large section of the population residing in various geographical areas. Nearly three billion people suffer
from either one or many parasitic infections globally, with almost one million deaths annually. In spite
of extensive research and advancement in the medical field, no effective vaccine is available against
prominent human parasitic diseases that necessitate identification of novel targets for designing specific
inhibitors. Vitamin B6 is an important ubiquitous co-enzyme that participates in several biological processes
and plays an important role in scavenging ROS (reactive oxygen species) along with providing
resistance to oxidative stress. Moreover, the absence of the de novo vitamin B6 biosynthetic pathway in
human parasites makes this pathway indispensable for the survival of these pathogens. Pyridoxal kinase
(PdxK) is a crucial enzyme for vitamin B6 salvage pathway and participates in the process of vitamers
B6 phosphorylation. Since the parasites are dependent on pyridoxal kinase for their survival and infectivity
to the respective hosts, it is considered a promising candidate for drug discovery. The detailed
structural analysis of PdxK from disease-causing parasites has provided insights into the catalytic
mechanism of this enzyme as well as significant differences from their human counterpart. Simultaneously,
structure-based studies have identified small lead molecules that can be exploited for drug discovery
against protozoan parasites. The present review provides structural and functional highlights of
pyridoxal kinase for its implication in developing novel and potent therapeutics to combat fatal parasitic
diseases.
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine