Affiliation:
1. Transplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013, China
2. Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China
Abstract
During inflammation, chemokines play a central role by mediating the activation of inflammatory
cascade responses in tissue injury. Among more than 200 chemokines, CX3CL1 is a special
chemotactic factor existing in both membrane-bound and soluble forms. Its only receptor, CX3CR1, is a
member of the G protein-coupled receptor superfamily. The CX3CL1/CX3CR1 axis can affect many
inflammatory processes by communicating with different inflammatory signaling pathways, such as
JAK-STAT, Toll-like receptor, MAPK, AKT, NF-κB, Wnt/β-catenin, as well as others. These inflammatory
networks are involved in much pathology. Determining the crosstalk between the
CX3CL1/CX3CR1 axis and these inflammatory signaling pathways could contribute to solving problems
in tissue injury, and the CX3CL1/CX3CR1 axis may be a better therapeutic target than inflammatory
signaling pathways for preventing tissue injury due to the complexity of inflammatory signaling
networks.
Publisher
Bentham Science Publishers Ltd.
Subject
Cell Biology,Molecular Biology,Biochemistry,General Medicine
Cited by
36 articles.
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