A Journey through the Cytoskeleton with Protein Kinase CK2-Reference-Cited by-同舟云学术

A Journey through the Cytoskeleton with Protein Kinase CK2

Published:2019-05-20 Issue:6 Volume:20 Page:547-562
ISSN:1389-2037
Container-title:Current Protein & Peptide Science
language:en
Short-container-title:CPPS

Author:

D'Amore Claudio¹,Salizzato Valentina¹,Borgo Christian¹,Cesaro Luca¹,Pinna Lorenzo A.¹,Salvi Mauro¹

Affiliation:

1. Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, Padova, Italy

Abstract

Substrate pleiotropicity, a very acidic phosphorylation consensus sequence, and an apparent uncontrolled activity, are the main features of CK2, a Ser/Thr protein kinase that is required for a plethora of cell functions. Not surprisingly, CK2 appears to affect cytoskeletal structures and correlated functions such as cell shape, mechanical integrity, cell movement and division. This review outlines our current knowledge of how CK2 regulates cytoskeletal structures, and discusses involved pathways and molecular mechanisms.

Funder

University of Padova

Italiana per la Ricerca sul Cancro

Fondazione per la Ricerca sulla Fibrosi Cistica

Publisher

Bentham Science Publishers Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,General Medicine

Reference150 articles.

1. Filhol O, Nueda A, Martel V, Gerber-Scokaert D, Benitez MJ, Souchier C, Saoudi Y, Cochet C. Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.

2. Bibby AC, Litchfield DW. The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta.

3. Litchfield DW. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death.