Affiliation:
1. Department of Chemistry, Faculty of Applied Science, Umm Al‐Qura University, Makkah, Saudi Arabia
2. Department
of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo,
Egypt
Abstract
Abstract:
Quinoxaline derivatives have been incorporated into numerous marketed drugs used for
the treatment of various diseases. Examples include glecaprevir (Mavyret), voxilaprevir (Vosevi),
Balversa (L01EX16) (erdafitinib), carbadox, XK469R (NSC698215), and becampanel (AMP397).
These quinoxaline derivatives exhibit a diverse range of pharmacological activities, including antibacterial, antitubercular, antiviral, anti-HIV, anti-inflammatory, antifungal, anticancer, antiproliferative, antitumor, kinase inhibition, antimicrobial, antioxidant, and analgesic effects. Recognizing the
significance of these bioactive quinoxaline derivatives, researchers have dedicated their efforts to
developing various synthetic methods for their production. This review aimed to compile the most
recent findings on the synthesis and biological properties of quinoxaline derivatives from 2015 to
2023.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
4 articles.
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