Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity

Author:

Sahu Rakesh12ORCID,Shah Kamal2ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, School of Medical and Allied Sciences, Galgotias University, Greater Noida-201310, India

2. Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura 281406, India

Abstract

Abstract:: One of the most important organic compounds, also known as a Schiff base, imine, or azomethine, has been associated with several biological processes. The group is a component of both natural or synthetic chemicals and functions as both a precursor and an intermediary in the synthesis of therapeutically active substances. The review highlights the various non-metal Schiff bases' structure-activity relationship (SAR) studies, general model, docking, and design approach for anticonvulsant actions. Schiff bases serve as linkers in numerous synthetic compounds with a variety of activities, according to the findings of several investigations. As a result, the current review will give readers a thorough understanding of the key ideas put forth by different researchers regarding the anticonvulsant properties of Schiff bases. It will serve as a valuable information source for those planning to synthesize new anticonvulsant molecules that contain Schiff bases as pharmacophores or biologically active moieties.

Publisher

Bentham Science Publishers Ltd.

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